LEP and obesity due to melanocortin 4 receptor deficiency: In agreement with our longitudinal findings, PKP2 was found to be diminished in SC adipose compartments of patients with obesity, especially in subjects with attendant impaired fasting glucose (Fig. 2d and Table S2), and thus inversely associated with BMI, the expression of leptin (LEP) (Fig. 2e), and percent fat mass, as well as biomarkers of an impaired metabolic control (Table S3).