The infiltration of immune cells in tumors was linked to the efficacy of ICI treatment.4 To evaluate whether A20 expression was associated with immune cells infiltration and prognosis of CRC patients, immunostaining using specific antibodies against tumorous A20 and a few immune cell markers in immune cells was conducted in 118 cases of CRC tumor specimens (Fig. 1b). Here, TNFAIP3 is linked to neoplasm.