BTRC and colorectal carcinoma: It has been reported that GSK3β is activated by A20 and it induces target protein phosphorylation, followed by degradation through the ubiquitin ligase SCF–β-TrCP1.25 In our CRC cell model, GSK3β was shown to interact with STC1 and decreased STC1 protein level by accelerating its degradation (Fig. 7n–r).