It has been reported that GSK3β is activated by A20 and it induces target protein phosphorylation, followed by degradation through the ubiquitin ligase SCF–β-TrCP1.25 In our CRC cell model, GSK3β was shown to interact with STC1 and decreased STC1 protein level by accelerating its degradation (Fig. 7n–r). This evidence concerns the gene GSK3B and colorectal carcinoma.