GZMB and neoplasm: However, significantly more tumor cell deaths and less secretions of cytokines (IL-6, IFN-γ, granzyme B and TNF-α) from the medium were observed in CRC cells with A20 overexpression than that in control cells and PBMCs co-culture system with matched HLA-A2 (Fig. 2a–e and Supplementary Fig. 1g–k).