TNFAIP3 and neoplasm: LCN2 was reported to induce inflammatory activation and brain metastases in multiple cancer types.30 KRT6A was a gene that mediates tumor-associated macrophage activity and tumors with high KRT6A have a hot immunophenotype with increased abundance of immune cells and increased activity of immune-related pathways.31 How they work in A20-mediated immune evasion need further study.