STC1 and neoplasm: It was reported that STC1 bound with CRT in mitochondria, thereby preventing the shift of CRT to the cell membrane, reducing the “eat-me” signals and protecting tumor cells from phagocytes by macrophages.18 We hypothesized that A20 induces STC1 overexpression and increases the retention of the CRT-STC1 complex in mitochondria, which subsequently inhibiting the shift of CRT to the cell membrane as an “eat-me” signal.