Cancer cells presenting the “eat-me” signal on their cell surface are recognized and phagocytosed by macrophage.12 Thus, impairment of the phagocytosis function of macrophages is associated with resistance of ICI therapy.18 To investigate whether A20-mediated tumor immune evasion was related to phagocytosis function of macrophages, the effect of CSF1R antibody (an inhibitor to deplete macrophages) on tumor growth inhibition was studied in a mouse model bearing CT26 cells. This evidence concerns the gene TNFAIP3 and neoplasm.