CALR and colorectal carcinoma: STC1 could capture the “eat-me” signal CRT protein inside cell to inhibit its translocation to cell membrane, which was recognized by macrophages to presenting antigens to CD8 + T cells.18 In our study, cell membranous CRT expression was notably increased in A20-silent CRC cells, whereas membranous CRT expression was remarkably reduced in A20-overexpressing CRC cells, thus unequivocally demonstrating the critical role played by A20 in regulating “eat-me” signals.