Cell membrane sourced from human melanoma cells A375 was also used here2, results showed that low-cholesterol membrane-coated PLGA nanoparticles (e.g., CAM) and their normal counterpart (e.g., nCAM) had similar targeting ability to A375 cells in vitro, and more CAM remained in the plasma after incubation with human blood (Supplementary Fig. 25f–i). The gene discussed is NCAM1; the disease is melanoma.