NOS2 and pancreatic ductal adenocarcinoma: Furthermore, CAFs can promote the growth of pancreatic ductal adenocarcinoma (PDAC) cell growth, and this effect increases when cells are cultured in conditioned media from RT-treated CAFs due to a substantial increase in inducible nitric oxide synthase (iNOS) secretion by CAFs after RT, which can be eliminated in vitro by iNOS depletion using genetic and pharmacological approaches [49].