PPARGC1A and Mitochondrial myopathy: These drugs include anti-diabetic drugs pioglitazone and rosiglitazone as well as by the lipid metabolism modifiers thiazolidinediones which increase PGC1α expression levels and enhance mitochondrial biogenesis.373–375 Meanwhile, 5-aminoimidazole-4-carboxamide ribonucleotide (AICAR), agonist directly activating PGC1α, has been demonstrated to enhance mitochondrial biogenesis by activating PGC1α, resulting in a partial repair of mitochondrial myopathy mice model.376