As for the IDH, previous studies have found that IDH-deficient mouse model has shown mitochondrial dysfunction and cardiac hypertrophy.222 Moreover, inhibition of complex I by mitochondria-targeted S-nitrosating agent MitoSNO has been used to decrease ROS production and cardiac IR injury.365 It is likely that many other agents that act in a similar way against type 2 diabetes. Here, IDH2 is linked to cardiac hypertrophy.