The interaction of ATP5B and SCAR abrogated mPTP by blocking induced by the cyclophilin D-mPTP interaction and therefore inhibited mROS production.48 Another highly expressed mecciRNA, mc-COX2, a sense RNA encoded by the COX2 locus, was found in the plasma exosomes of chronic lymphocytic leukemia (CLL) patients. This evidence concerns the gene RPS4X and B-cell chronic lymphocytic leukemia.