Research has suggested that nicotinamide nucleotide transhydrogenase (Nnt) mediates a reverse reaction in which NADPH is consumed to support NADH and ATP production under pathological heart conditions, which results in a reduction in NADPH-linked antioxidative capacity,227 Inhibition of Nnt led to the reversal of its catalytic function in a mouse model and protected against oxidative stress, HF, and death.227. The gene discussed is NNT; the disease is hydrops fetalis.