Additionally, we noticed an upregulation of osteoarthritis/inflammation-related genes (e.g., Ier3, Klf4, Cytl1) and a downregulation of chondroprotective genes (e.g., A2m, C1qtnf3, Matn1, Matn3)35–40 in the cKO growth plates (Fig. S5B). Here, A2M is linked to osteoarthritis.