The number of mitochondria present, along with their form and function, are highly tissue-dependent.[8,20,21] Brown adipose tissue (BAT) is rich in mitochondria, which are integral in the process of thermogenesis.[22] Brown adipocytes produce heat primarily through the uncoupling of the cristae’s proton gradient, which is facilitated through uncoupling protein 1 (UCP1).[23] In both rodent and human models, a decrease in BAT thermogenic function has been observed with advanced aging and has been associated with the development of metabolic disorders, including obesity and diabetes. This evidence concerns the gene UCP1 and metabolic disease.