IL1RL1 and allergic asthma: In an ovalbumin-induced (OVA-induced) relapsing-remitting mouse model of allergic asthma, Th2 cytokine–producing ST2+CD44+CD69+ Trm-Th2 cells were found to mediate allergen-induced disease relapse and maintain “allergic memory” in the lung for the lifetime of the mice (24).