We have shown that BCCs can engulf MSCs, generating a hybrid cancer cell population with phenotypic epithelial-to-mesenchymal transition (EMT) and expression of EMT proteins (e.g., Zinc Finger E-Box Binding Homeobox 1 [ZEB1] and smooth muscle actin [SMA]) as well as greater metastatic ability than nonengulfing BCCs (11). This evidence concerns the gene ZEB1 and cancer.