CALCA and neoplasm: In fact, the widely used oncogenic Kras-driven GEMMs of PDAC such as KC (p48-Cre; LSL-KrasG12D) or KPC (p48-Cre; LSL-KrasG12D; trp53lox/lox) did not exhibit PNI, although they harbored several enlarged nerves that were diffusely scattered in the tumor-infiltrated stroma.