Accordingly, the histological severity of NI, assessed by a clinically established scoring system (9, 17, 18) (0, the tumor cells in no contact with nerves; 1, the tumor cells perineurally touch the nerves, and 2, the tumor cells invade inside the nerve, Supplemental Figure 1D), was markedly higher in TPAC and TPC mice compared with the Kras-driven KC and KPC mutants (TPAC: 0.26 ± 0.10, TPC: 0.14 ± 0.09, KPC: 0.0 ± 0.0, KC: 0.0 ± 0.0) (Figure 1C and Supplemental Figure 1D). The gene discussed is KRAS; the disease is keratoconus.