Indeed, the index for proximity between cancer and nerves was significantly increased after treatment with rCCL2 and decreased after CCR4 inhibition compared with control mice (mean index: rCLL2: 0.64, C021: 0.2, control: 0.43; mean scores: rCCL2: 28.2, C021: 8.8, control: 16.00) (Figure 5, B and E). This evidence concerns the gene CCR4 and cancer.