CALCA and cancer: However, the forward migration index (FMI), which indicates directional chemotaxis, was much higher in TPAC cancer cells compared to the primary cancer cells of all other studied genotypes (TPAC: 0.32 ± 0.03, KC: 0.09 ± 0.04, KPC: –0.22 ± 0.05, TPC: 0.09 ± 0.03) (Figure 1E).