FGFR1 and cancer: In particular, the detected rearrangements in PDX003 and PDX008 showed strong similarities to those found in the FGFR inhibitor–responsive tumor from patient TUM009 and the cancer cell line H1581, indicating recurrent rearrangements associated with FGFR1 dependency (Figure 4D and Supplemental Figures 2, 10, and 11).