FGFR1 and squamous cell lung carcinoma: We therefore hypothesized that specific structural features of the 8p11 amplicon might explain FGFR1 dependency and performed an in-depth genomic and functional study of primary human squamous cell lung carcinomas from both patients treated with FGFR inhibitors as well as untreated patients, cancer cell lines, and patient-derived xenografts (PDXs).