Finally, we also constructed GSEA analysis, and the results showed cell cycle, ECM receptor interaction, oocyte meiosis, P53 signaling pathway and system lupus erythematosus were enriched in the COVID-19 group (Figure 4E), while allograft rejection, antigen processing and presentation, asthma, graft versus host disease and ribosome were enriched in the control group (Figure 4F). Here, TP53 is linked to lupus erythematosus.