CRISPLD2 and inborn error of immunity: As for CRISPLD2, the high expression group contained fatty acid biosynthesis, glycosaminoglycan biosynthesis, phenylalanine metabolism, starch and sucrose metabolism and tyrosine metabolism pathway, while low expression group contained allograft rejection, graft–versus–host disease, primary immunodeficiency, asthma and ribosome pathway (Figure 6B).