REN and inborn error of immunity: High F5 expression group was involved in ascorbate and aldarate metabolism, beta–Alanine metabolism, glycosaminoglycan degradation, pantothenate and CoA biosynthesis, renin–angiotensin system pathway, while low F5 expression group was involved in DNA replication, graft–versus–host disease, primary immunodeficiency, proximal tubule bicarbonate reclamation and ribosome pathway (Figure 6C).