Their potential asbiomarkers for neurodegenerative disease has already been reported.61,62 Our results strongly imply that nucleotide-interacting proteinsrarely constitute good fluid CSF biomarkers, which may explain thedifficulty to develop fluid biomarker tests for the frontotemporaldementia-related protein TDP-43.63 The gene discussed is TARDBP; the disease is neurodegenerative disease.