TP53 and cancer: Moreover, a 2023 meta-analysis4 of randomized clinical trials (RCTs) found that daily vitamin D3 supplementation was associated with improved cancer mortality in the general population and survival in patients with cancer, although the results are still controversial.5 Beneficial effects of vitamin D have been reported for cancers at various sites, and p53 oncosuppressor is the most frequently mutated gene in approximately half of cancers and relatively common across cancers at all primary sites.