Phosphorylation has received most attention because it is believed that Tau pathology arises, at least in part, from the impaired ability of phosphorylated Tau to bind to MTs; cytosolic accumulation of phospho-Tau has been proposed to precede Tau aggregation, leading to neuronal degeneration in AD and tauopathies (Gong and Iqbal 2008). This evidence concerns the gene MAPT and tauopathy.