However, even the very low TauΔK280 expression in our EC/TauΔK mice was sufficient to induce Tau changes in the EC reminiscent of early pathological alterations in AD: we observed phosphorylated Tau (pS262/pS356) and pathological conformation (MC1 antibody) in the EC of pro-aggregant TauΔK mice as early as 3 months. Here, ATP7A is linked to Alzheimer disease.