Gilteritinib is currently the only FLT3 inhibitor approved for patients with relapsed or refractory (R/R) AML [3], based on the positive results of the pivotal ADMIRAL study: the median overall survival (OS) was significantly longer in patients treated with gilteritinib than among patients receiving any type of chemotherapy (9.3 vs. 5.6 months) [4]. Here, FLT3 is linked to acute myeloid leukemia.