NF-κB signaling is a hallmark that promotes lymphoma growth and survival by activating anti-apoptotic and pro-proliferative gene programs in many lymphoid malignancies including HL, diffuse large B-cell lymphoma (DLBCL), mucosa-associated lymphoid tissue (MALT) lymphoma, primary effusion lymphoma and adult T-cell lymphoma/leukemia (ATLL) [7,8]. Here, NFKB1 is linked to diffuse large B-cell lymphoma.