For example, in Shwachman–Diamond syndrome, germline mutation of the SBDS gene, whose protein product removes EIF6 from the 60S subunit to help the association of 60S and 40S subunits to form the 80S subunit, causes the accumulation of free 60S subunits, leading to the activation of the TP53-mediated stress pathway [65]. Here, SBDS is linked to Shwachman-Diamond syndrome.