In the context of specialised function of ribosomal constituents, in T-cell acute lymphoblastic leukaemia, loss of function of RPL22 (and not its paralogue RPL22L, as mentioned later for glioblastoma) was reported in 10% cases, in association with the expression of stemness factor Lin28B via NF-kB, leading to cancer, referring to RPL22′s extraribosomal role [54]. This evidence concerns the gene RPL22 and cancer.