The increase in IL-6 prior to the elevation of CRP follows previous literature on the diagnostic capability of IL-6 and CRP together, as reported by Tessema and others [37,38,39], it is also consistent with the well-described effect of IL-6 on subsequent CRP production [40], and it is very reminiscent of the results seen in late-onset culture-proven sepsis [41]. This evidence concerns the gene IL6 and Sepsis.