MAPT and early-onset autosomal dominant Alzheimer disease: Particularly, as DC11 and MN423 recognize conformational epitopes on tau protein folded in disease-related filaments in Alzheimer’s disease [36,38], we aimed to co-crystallize these antibodies with recombinant fragment of intrinsically disordered tau protein dGAE, found in the core of Alzheimer’s filaments [24].