In one trial evaluating 17 patients with paraneoplastic encephalomyelitis/sensory neuropathy (PEM/SN) with anti-Hu Abs (n = 10) or cerebellar degeneration (PCD) with anti-Yo Abs (n = 7), treatment with IVIG, methylprednisolone and cyclophosphamide demonstrated a significant decrease in antibody titers in six of seven evaluable patient but with no associated clinical or survival benefit [65]. Here, CDR2 is linked to sensory peripheral neuropathy.