Meanwhile, Wu et al. (2021), also utilizing iTRAQ and mass spectrometry, identified three proteins (PROZ, TNFRSF6B, and TNFRSF6B) that, when combined, could provide an AUC of 0.932 for early-stage pancreatic cancer detection [131]. The gene discussed is TNFRSF6B; the disease is familial pancreatic carcinoma.