Further studies on the relationship of mutated CHMP2B with Golgi stress are needed to increase our understanding of the detailed mechanisms by which the FTD/ALS7-associated mutation of CHMP2B inhibits neuronal morphological differentiation using cells and genetically modified mice, as well as of a possible causal relationship between inhibitory differentiation and the early stages of neurodegeneration in FTD/ALS7. This evidence concerns the gene CHMP2B and frontotemporal dementia.