Elevated C-MYC oncogene expression was detected in 13 AML patients, including FLT3-ITD-negative (AML1-ETO, n = 5; CBFβ-MYH11/A, n = 2; normal karyotype, n = 2) and FLT3-ITD-positive (n = 4) patients. Here, RUNX1 is linked to acute myeloid leukemia.