Mechanistically, the overexpression of SELENBP1 was uncovered to inhibit cell growth by decreasing the protein expression of hypoxia‐inducible factor‐1α (HIF‐1α) in prostate cancer cells,23 and remarkably restrained cell growth through activating p21 with p53‐independent way in bladder cancer cells.26 Here, SELENBP1 is linked to Familial prostate cancer.