To further determine whether activation of PI3K/Akt/mTOR signaling was mediated by overexpression of SELENBP1 in NSCLC cells, we then investigated the effects of specific PI3K or Akt inhibitor and PI3K/AKT activator on the malignant characteristics of NSCLC cells, respectively. This evidence concerns the gene AKT1 and non-small cell lung carcinoma.