The two groups did not differ by age at acromegaly diagnosis, sex, BMI, GH, and IGF-I levels at acromegaly diagnosis, prevalence of hypopituitarism, prediabetes/diabetes mellitus, or central adrenal insufficiency, daily dose of hydrocortisone (or equivalent), prevalence of central hypogonadism or menopause, and class of drug for acromegaly treatment. The gene discussed is IGF1; the disease is acromegaly.