Other reports have suggested that free VD is decreased in acromegaly and that tt (TaqI), aa (ApaI), and bb (BsmI) polymorphisms of the VDR gene may be associated with better bone quality and microarchitecture (higher trabecular bone score), which lead to a lower risk of osteoporotic fractures in acromegaly patients (34, 35). The gene discussed is VDR; the disease is acromegaly.