Yan et al. indicated that miR-22 directly binds to the 3’-UTR of HuR, leading to the inhibition of HuR protein, further inhibiting the proliferation and migration of CRC in vitro and slowing the growth of CRC xenograft tumors in vivo.32 However, recent experimental results indicated that circRNAs could break the stabilization and translation of mRNAs by competitively binding with HuR.33 In this study, we found that overexpression of circSETD2 had no effect on HuR expression at either the mRNA or protein level. This evidence concerns the gene ELAVL1 and colorectal carcinoma.