Following TLR stimulation of SLE ACT whole blood, a subset of pro-inflammatory cytokines was increased, including CXCL13, IL-13, IL-6, SCF, and TNF-β, with other cytokines also trending higher (Figure 8K, Supplemental Figure 42, and Supplemental Tables 24 and 25). This evidence concerns the gene CXCL13 and systemic lupus erythematosus.