All controls were female, had a mean age of 29.2 years, had no clinical symptoms of autoimmune disease as determined by a connective tissue screening questionnaire (CSQ) (33), were antinuclear antibody (ANA) negative by HEp-2 immunofluorescence and by Bio-Rad Bioplex 2200 ANA, and had no anti–cyclic citrullinated peptide (anti-CCP) or rheumatoid factor–specific (RF-specific) autoantibodies (data not shown). Here, BTG3 is linked to autoimmune disease.