MAFA and type 2 diabetes mellitus: To this end, we compared the gene regulatory properties of these TFs across multiple conditions — including direct genetic manipulation of MafA in mouse islet β cells, MAFAKD and MAFBKD in human EndoC-βH1/2 β cells, MAFBKO in hESC-derived β-like cells, and MAFBKD in human pseudoislets as well as in pathophysiologic conditions — in mouse models and human T2D islets.