The expression level of gene sets related to cytotoxic T cell activation (perforin, granzyme A, and granzyme B), costimulation (CD80 and CD86), and immune checkpoints (LAG3, CTLA4, PD-L1, and PD-1) was found to be increased in the tumor tissue (Figure 1C). The gene discussed is GZMB; the disease is neoplasm.