These data were supported by analyzing available single-cell RNA-sequencing (scRNASeq) profiles of explanted lung tissue from patients with advanced COPD or control lungs, which demonstrated that FASN was predominantly enriched in a subpopulation of surfactant-producing AEC2 cells (associated with canonical “bulk” AEC2 markers such as SFTPA1, SFTPA2, and ETV5 and termed AT2B cells) (34) (Figure 2B and Supplemental Figure 2A). This evidence concerns the gene ETV5 and chronic obstructive pulmonary disease.