Thus, A2AR antagonists blocked the anti-inflammatory effects of CBD (Liou et al., 2008; Ribeiro et al., 2012; Mecha et al., 2013; Oláh et al., 2014), or the ability of CBD to blunt Δ9-THC-induced cognitive impairment (Aso et al., 2019). This evidence concerns the gene OPN1MW and Cognitive impairment.