TNF and temporal lobe epilepsy: In an experiment executed 2020, it was shown that LncRNA through activation of the PI3K/AKT/ mTOR pathway could decrease inflammation (IL-1β, IL-6, and TNF-α) and apoptosis (Caspase-3, Bax, and Bcl-2) in the hippocampus, and could increase cell viability in spontaneous recurrent epileptiform discharges (SREDs) or temporal lobe epilepsy (TLE) (61).