In this regard, Han et al. (2016) reported that IL-1β receptor antagonists could improve LTP impairment through the decrease of the p-Akt/Akt ratio expression in the PTZ rats (Han et al. 2016b)which result from synchronized aberrant firing of neuronal populations, can cause long-term sequelae, such as epilepsy, cognitive and behavioral issues, in which the synaptic plasticity alteration may play an important role. This evidence concerns the gene AKT1 and epilepsy.