Reduction in β-catenin, α-SMA, Vimentin, and Collagen I in mRNA and protein levels;Reduction in the mRNA levels ofC-myc and cyclin D1 (two Wnt downstream genes related to celldifferentiation), preventing TGF-β1-stimulated myofibroblast differentiation of LR-MSCs, and retardingBLM-induced pulmonary fibrosis. The gene discussed is CCND1; the disease is pulmonary fibrosis.