Moreover, transfection of LR-MSCs with LV (lentivirus vector)-Fzd10-siRNA remarkably repressed TGF-β1-stimulated myofibroblast differentiation of LR-MSCs and diminished bleomycin-stimulated PF through the decrease in Fzd10, Col1a1 and α-SMA expression at protein and mRNA levels (90). The gene discussed is TGFB1; the disease is pemphigus foliaceus.