There were 7 common GM-related genes in POAG patients in the 10 most prominent pathways, which are CCL16, nuclear factor kappa B subunit 1(NFKB1), interleukin 18(IL18), KITLG, TLR9, MUC2, and HDAC4. The gene discussed is NFKB1; the disease is open-angle glaucoma.