However, its silencing by RNA interference (RNAi) technology was found to increase chemosensitivity of Ara-C and apparently reduce mRNAs of both MMP-2 and MMP-9 in acute myeloid leukemic cell line (U937), indicating B7-H3 involvement in transcriptional regulation of these two genes [129], which plays a central role in tumor migration, invasion, and metastasis [130]. This evidence concerns the gene MMP9 and neoplasm.