Concurrently, another report demonstrated that B7-H3 promotes the Warburg effect (i.e., increased glucose uptake and lactate production) in breast cancer cells by inducing hypoxia-inducible factor (HIF)-1α and its downstream enzymes, e.g. lactate dehydrogenase (LDH)-A and pyruvate dehydrogenase kinase 1 (PDK1) of the glycolytic pathway, resulting in tumor growth [139]. This evidence concerns the gene CD276 and breast cancer.