There is a vast number of potential target genes regulated by miR‐15a‐5p or/and miR‐199a‐3p, which are involved in atherosclerosis, lipid metabolism and inflammation, including mTOR,31 ET‐1,27 YAP,32 CXCL11,33 CD44,34 MAP3K4,35 p65,36 IKKα/β,37 ICAM‐138 and p85α.39 This evidence concerns the gene EDN1 and atherosclerosis.