In this study, a meta-analysis was carried out for the diagnostic efficacy of PET/CT with different imaging agents, and the results suggested that 18 F-PSMA-1007 PET/CT and 68Ga-PSMA PET/CT had higher diagnostic efficacy of prostate cancer compared with 18 F-FDG PET/CT, among which 68Ga-PSMA PET/CT was slightly higher in the sensitivity of the diagnosis of prostate cancer, while 18 F-PSMA-1007 PET/CT may have higher efficacy in specificity and confirmed positive rate. Here, FOLH1 is linked to Familial prostate cancer.