In AD-TDP, four (STMN2, KCNQ2, UNC13A, SYT7) out of the five cryptic RNA were able to distinguish TDP-43 cases from controls, in both amygdala and hippocampus, although the significance and AUC values were lower in the latter region (Fig. 3A). This evidence concerns the gene KCNQ2 and Alzheimer disease.