The criteria for selecting these specific areas were based on TDP-43 deposition scheme in AD that describes an initial TDP-43 accumulation in the amygdala (stage 1) followed by pathology in hippocampus and occipitotemporal gyrus (stages 2–3), basal forebrain and ventral striatum (stages 4–5) and last in the frontal cortex (stage 6) (Fig. 1A) [21–23]. Here, TARDBP is linked to Alzheimer disease.