TARDBP and Alzheimer disease: Our study cohort included a total of 192 postmortem cases classified into four main groups: 27 cognitively normal (CN) cases (median Braak NFT stage II, Thal phase 0), 27 AD cases without TDP-43 pathology (AD no TDP), 71 AD cases with confirmed TDP-43 pathology (AD-TDP), and 67 FTLD-TDP cases (Table 1).