TARDBP and Alzheimer disease: Dysfunction of TDP-43 in FTLD-TDP and AD-TDP also causes missplicing in the potassium channel regulator KCNQ2. In contrast to the other cryptic splicing events, loss of TDP-43 leads to the exclusion of an in-frame canonical exon in KCNQ2, rather than the inclusion of a novel exon.