In particular, cryptic RNAs encoded from STMN2 (neuronal growth, axonal regeneration, signal transduction), KCNQ2 (neuronal excitability), UNC13A (neurotransmitter release at the synapse), CAMK2B (neuronal plasticity and synapse formation), and SYT7 (exocytosis of secretory and synaptic vesicles) have been validated in frontal cortex of ALS and FTLD-TDP [29, 34, 35]. The gene discussed is KCNQ2; the disease is amyotrophic lateral sclerosis.