The results showed that the levels of plasma inflammatory factors TNF-α (Fig. 5A), IFN-γ (Fig. 5B), and IL-6 (Fig. 5C) in MD group were significantly lower than those in Ctrl group, and the levels of TNF-α (Fig. 5A), IL-6 (Fig. 5C) and IL13 (Fig. 5D) in HD group were significantly lower than those in Ctrl group. Here, TNF is linked to Menkes disease.