Androgens can up-regulate the activity of transmembrane serine protease 2 (TMPRSS2), which is required for the initiation of infection by SARS-CoV-2 [3] by promoting the interaction between the receptor-binding domain of the S1 subunit on SASR-CoV-2 spike glycoprotein and the angiotensin-converting enzyme 2 (ACE2) ectodomain and causing SARS-CoV-2 entry into human cells [4]. This evidence concerns the gene ACE2 and infection.