SPRED2 and hepatocellular carcinoma: In addition, some other persistent genes have been implicated in liver damage and fibrosis (e.g., dax1, gadd45a, tsc22d3, and miR-122) [65–68] and HCC (e.g., spred2, scube1, ptprfb, tmod1, asap3, zbtb16, and hhla2b1) [69–75].