When stratifying by APOE status, the associations were weaker amongst those with a higher genetic risk of dementia (ε4/ε4 or ε3/ε4), and stronger amongst those with a normal (ε3/ε3) and lower (ε2/ε2 or ε3/ε2) genetic risk of dementia (Table 4). This evidence concerns the gene APOE and dementia.