Finally, in the 51 patients (74.5% pubertal and 25.5% prepubertal) who underwent the GnRH test for the diagnosis of central precocious puberty, the mean peak LH (pLH) reached in the prepubertal group after pharmacological stimulation was 3.2 IU/L ± 1.02 (≤ 5 IU/L), while for the pubertal group it was 14.05 IU/L ± 12.85 (> 5 IU/L) (p < 0.05). This evidence concerns the gene PLOD1 and precocious puberty.