AKT1 and neoplasm: Oxidative phosphorylation increases in macrophages in response to let-7a exosomal miR released by the hypoxic tumor cells, leading to the promotion of M2 macrophages and suppression of insulin-Akt-mammalian target of rapamycin (mTOR) signaling pathway [51, 52] (Fig. 2b) and (Table 1).