TCMSini's San (SNS), used for depression-related symptoms, was shown to attenuate GRP78 expression, preventing its interaction with LRP5 on the cell surface and inhibiting breast cancer stem cell signaling through the Wnt and β-catenin pathway(Zheng et al. 2021; Liu et al. 2022; Sadeghipour et al. 2022). The gene discussed is HSPA5; the disease is breast cancer.