The researchers observed downregulation of GRP78 and matrix metallopeptidase proteins 2&9 (MMP2&9) transcript levels, along with increased expression of tissue inhibitor of metalloproteinase proteins 1&2 (TIMP1&2), suggesting that sFLT01 inhibited cancer cell proliferation and invasiveness (Taghizadeh et al. 2021). The gene discussed is HSPA5; the disease is cancer.