HSPA5 and neoplasm: The CAR T cells induced the production of anti-tumor cytokines and effectively suppressed tumor progression in preclinical models (Yu et al. 2022) (Fig. 6).Recently, the activation of GRP78 ATPase by ZBM-H has been shown to suppress A549 lung cancer cell migration by promoting the degradation of integrin β4 (ITGB4).