The 12 (six positive and six negative) non-zero predictors from aLASSO logistic regression were IAG, age, sex, MMSE score, homozygous APOE-ɛ4 vs none, heterozygous APOE-ɛ4 vs. none, married vs single, widowed vs. single, prevalent stroke vs. not, physical active vs. inactive, Düsseldorf vs. Bonn, and Munich vs. Bonn (Fig. 3A). The gene discussed is APOE; the disease is stroke disorder.