This included five gut microbiome molecules (IAG, ILA, IAA ME, isobutyric acid, 2-methylbutyric acid) and 13 covariates (age, sex, MMSE score, homozygous APOE-ɛ4 vs none, heterozygous APOE-ɛ4 vs. none, married vs single, widowed vs. single, serotonin, tryptophan, prevalent stroke vs. not, physical active vs. inactive, study center Düsseldorf vs. Bonn, and study center Munich vs. Bonn). This evidence concerns the gene APOE and stroke disorder.