APOE and Stroke: This included five gut microbiome molecules (IAG, ILA, IAA ME, isobutyric acid, 2-methylbutyric acid) and 13 covariates (age, sex, MMSE score, homozygous APOE-ɛ4 vs none, heterozygous APOE-ɛ4 vs. none, married vs single, widowed vs. single, serotonin, tryptophan, prevalent stroke vs. not, physical active vs. inactive, study center Düsseldorf vs. Bonn, and study center Munich vs. Bonn).