Moreover, MXD has been suggested to have an inhibitory effect on the canonical transforming growth factor (TGF)β1 pathway in lung myofibroblasts after treatment in a mouse model of bleomycin-induced-pulmonary fibrosis that resulted in weakened bronchioalveolar COL1 fibrillogenesis [41]. Here, TGFB1 is linked to pulmonary fibrosis.