However, studies on the Plod2-mediated formation of COL1 networks that promote migration of metastatic neoplasms suggest that MXD may directly interfere with transcription of Plod2 [12] and that inhibition of the Plod2-LH axis has an adverse effect on the structural integrity and assembly of mature COL1 rather than COL1 transcription and synthesis itself [19]. Here, PLOD2 is linked to metastatic neoplasm.