Our study aimed to investigate the relation of VWF release and clearance with PH and liver disease severity in a large cohort of patients with ACLD undergoing HVPG measurement, by measuring VWF propeptide (VWF-N; reflecting release from endothelial cells), VWF antigen levels (VWF-Ag), and ADAMTS13-cleaved VWF (VWF-A). This evidence concerns the gene VWF and liver disorder.