In our cohort of patients with stable cirrhosis (i.e. absence of acute decompensation or infections), that marks a difference to other cohorts investigating the prognostic value of VWF e.g. in acute-on-chronic liver failure [41, 42], we found that systemic inflammation increased with PH severity—as reported previously in this cohort [18]—but was not linked to ADAMTS13-Act. This evidence concerns the gene VWF and chronic liver failure.