By annotating against two mouse tumour model scRNA-seq datasets, we found that Mac Mrc1, which accumulated in the dKO (Fig. 3d), was fully encompassed by Mac_s2, tumour-enriched macrophages that become depleted following immune checkpoint blockade52, and by Mac1, the human counterpart of which is associated with poor prognosis in patients with lung adenocarcinoma53 (Extended Data Fig. 3j,k). This evidence concerns the gene MRC1 and neoplasm.